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KARISMA is a sterile, resorbable, polycomponent injectable described in Europe as a Class III medical device. “Rh Collagen” refers to recombinant human collagen technology. The manufacturer states that the recombinant polypeptide is produced using transgenic silkworm technology. It is not extracted from human donors, it is not cadaver-derived, and it does not contain living stem cells.
KARISMA is a sterile, resorbable, polycomponent injectable described in Europe as a Class III medical device. “Rh Collagen” refers to recombinant human collagen technology. The manufacturer states that the recombinant polypeptide is produced using transgenic silkworm technology. It is not extracted from human donors, it is not cadaver-derived, and it does not contain living stem cells.
01 / How it works
The formulation acts through three complementary components. The Rh collagen polypeptide may support a collagen-related biological response, while the non-crosslinked hyaluronic acid supports temporary hydration and tissue softness. Finally, CMC contributes to the physical behaviour of the carrier. Patients from Mount Austin, Taman Pelangi, and Singapore appreciate that we carefully explain these ingredients. We clarify that injection creates an immediate soft-tissue effect primarily from swelling, and any collagen-related skin-quality changes develop gradually.
KARISMA is a sterile, resorbable, polycomponent injectable described in Europe as a Class III medical device. “Rh Collagen” refers to recombinant human collagen technology. The manufacturer states that the recombinant polypeptide is produced using transgenic silkworm technology. It is not extracted from human donors, it is not cadaver-derived, and it does not contain living stem cells.
The formulation acts through three complementary components. The Rh collagen polypeptide may support a collagen-related biological response, while the non-crosslinked hyaluronic acid supports temporary hydration and tissue softness. Finally, CMC contributes to the physical behaviour of the carrier. Patients from Mount Austin, Taman Pelangi, and Singapore appreciate that we carefully explain these ingredients. We clarify that injection creates an immediate soft-tissue effect primarily from swelling, and any collagen-related skin-quality changes develop gradually.
Share the concern, treatment area and change you would like to explore
Shape the approach around your features, preferences and schedule
Experience a carefully planned session with clear guidance throughout
Follow simple aftercare and review how the treatment is progressing

02 / Visual guide
KARISMA is a sterile, resorbable, polycomponent injectable described in Europe as a Class III medical device. “Rh Collagen” refers to recombinant human collagen technology. The manufacturer states that the recombinant polypeptide is produced using transgenic silkworm technology. It is not extracted from human donors, it is not cadaver-derived, and it does not contain living stem cells.
Interactive treatment map
Tap a numbered point to move from your concern to the treatment approach, how it works and a personalised plan.

Start with the change you have noticed and the result you would like to explore.
Concerns & areas
Explore common areas and goals, then discuss which are most relevant to you.
Learn how this area can be approached within a personalised treatment plan.
Who may benefit
What to discuss first
03 / Your treatment journey
A calm, well-explained experience at every stage.
Talk through the concern, your previous experiences and the result you would like to explore.
Review the treatment area, suitable options, expected experience and practical timing.
Arrive prepared and receive clear guidance throughout the treatment visit.
Leave with simple aftercare, helpful contact details and a plan for review.
While serious complications are uncommon, accidental injection into or obstruction of a blood vessel can cause tissue injury. Warning signs of reduced blood flow include severe pain, unusual blanching, mottled discolouration, or visual disturbance. Visual symptoms require immediate emergency medical assessment. It is important to know that hyaluronidase acts on hyaluronic acid but should not be described as completely dissolving every component of KARISMA.
04 / Practical expectations
Your experience will reflect the selected treatment, treatment area and individual response. These are the useful details to explore during your visit.
05 / Compare your options
Compare the treatment approach, the area it is designed for, the experience and the way results may develop—not only the name or price.
A useful starting point when you already know the treatment and want to understand it more clearly.
Opens a wider conversation about suitable approaches, timing, recovery and natural-looking results.
Treatment gallery
Explore the consultation, treatment setting and preparation through a carefully selected visual story.
Related concerns
Begin with the concern you notice, then discover treatment approaches and questions worth bringing to your consultation.
Patient knowledge guide
Four short questions explain the treatment, suitability and why assessment matters. This quiz educates—it does not diagnose or confirm treatment eligibility.
06 / Before you decide
Prohibited Treatment Areas: This section is critical. The reviewed product instructions state that KARISMA should not be injected into the periorbital area (including eyelids and the crow’s-feet region) or the glabellar region. We do not offer or advertise treatment in these areas.
Suitability depends on your medical history. Patients with active inflammation, autoimmune connective-tissue diseases, pregnancy, or uncontrolled epilepsy are typically not suitable. The current locally supplied instructions must be checked before every treatment.
Read about informed consent07 / Recovery
While serious complications are uncommon, accidental injection into or obstruction of a blood vessel can cause tissue injury. Warning signs of reduced blood flow include severe pain, unusual blanching, mottled discolouration, or visual disturbance. Visual symptoms require immediate emergency medical assessment. It is important to know that hyaluronidase acts on hyaluronic acid but should not be described as completely dissolving every component of KARISMA.
Contact the clinic08 / FAQ
Helpful answers for planning your consultation and understanding the treatment experience.
KARISMA is a sterile, resorbable, polycomponent injectable described in Europe as a Class III medical device. “Rh Collagen” refers to recombinant human collagen technology. The manufacturer states that the recombinant polypeptide is produced using transgenic silkworm technology. It is not extracted from human donors, it is not cadaver-derived, and it does not contain living stem cells.
No. The manufacturer describes its collagen component as a recombinant type-I collagen alpha-chain polypeptide produced using transgenic silkworm technology. It is not donor or cadaver tissue.
The reviewed product instructions state that KARISMA should not be injected into the periorbital area, including the eyelids and crow’s-feet region. The current locally supplied instructions must always be followed.
The reviewed instructions exclude the glabellar region. A clinic should not advertise treatment in an area that is prohibited by the current product instructions.
Temporary redness, swelling, bruising, tenderness, bleeding, tightness or warmth may occur. Downtime varies according to the treatment area and individual response.
Serious complications are uncommon but may include infection, significant inflammatory reactions and vascular compromise. Reduced blood flow can cause tissue injury, and visual symptoms require immediate medical assessment.
Plan your next step
Share your goals with the Eco Botanic team and begin with a personalised consultation.