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PBSerum HA Medium and High are injectable medical-device formulations containing sodium hyaluronate and recombinant collagenase, lipase and lyase. Medium is associated with fatty fibrosis, while High is associated with more pronounced collagen-rich fibrosis. A doctor must assess which formulation, if either, is suitable.
PBSerum HA Medium and High are injectable medical-device formulations containing sodium hyaluronate and recombinant collagenase, lipase and lyase. Medium is associated with fatty fibrosis, while High is associated with more pronounced collagen-rich fibrosis. A doctor must assess which formulation, if either, is suitable.
01 / How it works
Collagenase is associated with the breakdown and remodelling of non-functional collagen, lipase targets adipose-related tissue components, and lyase supports extracellular-matrix fluidity and tissue permeability. Because every patient’s tissue structure is unique, the formulation is selected according to the tissue pattern identified by the doctor. Medium focuses on fatty fibrosis with a higher fat content, while High addresses more pronounced fibrosis with a higher collagen content. Our patients appreciate that we prioritise steady, medically appropriate tissue remodelling over aggressive, one-size-fits-all fixes.
PBSerum HA Medium and High are injectable medical-device formulations containing sodium hyaluronate and recombinant collagenase, lipase and lyase. Medium is associated with fatty fibrosis, while High is associated with more pronounced collagen-rich fibrosis. A doctor must assess which formulation, if either, is suitable.
Share the concern, treatment area and change you would like to explore
Shape the approach around your features, preferences and schedule
Experience a carefully planned session with clear guidance throughout
Follow simple aftercare and review how the treatment is progressing

02 / Visual guide
PBSerum HA Medium and High are injectable medical-device formulations containing sodium hyaluronate and recombinant collagenase, lipase and lyase. Medium is associated with fatty fibrosis, while High is associated with more pronounced collagen-rich fibrosis. A doctor must assess which formulation, if either, is suitable.
Interactive treatment map
Tap a numbered point to move from your concern to the treatment approach, how it works and a personalised plan.

Start with the change you have noticed and the result you would like to explore.
Concerns & areas
Explore common areas and goals, then discuss which are most relevant to you.
Learn how this area can be approached within a personalised treatment plan.
Learn how this area can be approached within a personalised treatment plan.
Learn how this area can be approached within a personalised treatment plan.
Learn how this area can be approached within a personalised treatment plan.
Who may benefit
Not all localised fullness or scars are suitable for PBSerum. This is why a doctor’s assessment is mandatory.
Tissue Assessment: Our doctor physically examines the area to determine if the concern primarily involves adipose tissue, fluid, collagen-rich fibrosis, skin laxity, or an undiagnosed lump.
What to discuss first
03 / Your treatment journey
A calm, well-explained experience at every stage.
Talk through the concern, your previous experiences and the result you would like to explore.
Review the treatment area, suitable options, expected experience and practical timing.
Arrive prepared and receive clear guidance throughout the treatment visit.
Leave with simple aftercare, helpful contact details and a plan for review.
Your treatment journey begins with a transparent discussion of your medical history, previous aesthetic procedures, and realistic goals. If suitable, the registered medical device is professionally prepared and administered using sterile intradermal techniques.
Follow-up Reviews: Tissue remodelling takes time, and we schedule clinical reviews after initial swelling settles to monitor your progress safely.
The potential benefit of this treatment is the improvement in tissue flexibility, texture, or contour in appropriately selected areas. However, PBSerum HA Medium or High cannot be selected simply based on price, nor are they automatically combined. One session is not guaranteed to be sufficient; the treatment plan depends on the area, severity, and individual response. Some patients may require a series of sessions. Whether you live in Mount Austin, Iskandar Puteri, or are a Singapore visitor, we focus on safe, natural-looking improvements rather than risking your tissue health with overly aggressive procedures.
While PBSerum recombinant enzyme treatment is a non-surgical option in selected cases, it is a medical procedure with expected downtime. Common temporary side effects include redness, swelling, tenderness, bruising, discomfort, and temporary firmness or unevenness at the injection points. Less common but important complications can include significant inflammatory reactions, prolonged swelling, infection, delayed healing, or hypersensitivity.
Because temporary swelling may initially make the area look different, tissue changes are not necessarily immediate. Your aftercare habits are essential. You must keep the treated area clean, avoid pressing or massaging the area unless explicitly instructed, and skip strenuous exercise and excessive heat exposure as advised by the doctor. If you experience rapidly worsening pain, marked heat, fever, or severe swelling, you must contact the clinic for prompt medical assessment. By setting realistic expectations and providing detailed post-treatment guidance, we help patients safely navigate their recovery.
04 / Practical expectations
Your experience will reflect the selected treatment, treatment area and individual response. These are the useful details to explore during your visit.
05 / Compare your options
Compare the treatment approach, the area it is designed for, the experience and the way results may develop—not only the name or price.
A useful starting point when you already know the treatment and want to understand it more clearly.
Opens a wider conversation about suitable approaches, timing, recovery and natural-looking results.
PBSerum Medium focuses more on tissue with an adipose or fatty-fibrosis component. PBSerum High focuses more on harder, collagen-rich fibrotic tissue. High is not automatically stronger or better, and the two products should not be selected according to price or marketing claims.
Treatment gallery
Explore the consultation, treatment setting and preparation through a carefully selected visual story.
Related concerns
Begin with the concern you notice, then discover treatment approaches and questions worth bringing to your consultation.
Patient knowledge guide
Four short questions explain the treatment, suitability and why assessment matters. This quiz educates—it does not diagnose or confirm treatment eligibility.
06 / Before you decide
Each treatment has its own considerations. Your consultation is the place to discuss expected benefits, possible side effects, alternatives and anything that may affect timing.
Read about informed consent07 / Recovery
While PBSerum recombinant enzyme treatment is a non-surgical option in selected cases, it is a medical procedure with expected downtime. Common temporary side effects include redness, swelling, tenderness, bruising, discomfort, and temporary firmness or unevenness at the injection points. Less common but important complications can include significant inflammatory reactions, prolonged swelling, infection, delayed healing, or hypersensitivity.
Because temporary swelling may initially make the area look different, tissue changes are not necessarily immediate. Your aftercare habits are essential. You must keep the treated area clean, avoid pressing or massaging the area unless explicitly instructed, and skip strenuous exercise and excessive heat exposure as advised by the doctor. If you experience rapidly worsening pain, marked heat, fever, or severe swelling, you must contact the clinic for prompt medical assessment. By setting realistic expectations and providing detailed post-treatment guidance, we help patients safely navigate their recovery.
Contact the clinic08 / FAQ
Helpful answers for planning your consultation and understanding the treatment experience.
Your treatment journey begins with a transparent discussion of your medical history, previous aesthetic procedures, and realistic goals. If suitable, the registered medical device is professionally prepared and administered using sterile intradermal techniques.
PBSerum HA Medium and High are injectable medical-device formulations containing sodium hyaluronate and recombinant collagenase, lipase and lyase. Medium is associated with fatty fibrosis, while High is associated with more pronounced collagen-rich fibrosis. A doctor must assess which formulation, if either, is suitable.
PBSerum Medium focuses more on tissue with an adipose or fatty-fibrosis component. PBSerum High focuses more on harder, collagen-rich fibrotic tissue. High is not automatically stronger or better, and the two products should not be selected according to price or marketing claims.
PBSerum HA 2.0 Low, Medium and High are listed in Malaysia’s Medical Device Authority register under one registered device family. Registration status and the exact product used should still be reconfirmed at the time of treatment.
PBSerum Medium should not be presented as a weight-loss treatment or a solution for general obesity. It may be considered for selected localised areas with a fatty-fibrosis component, but it does not treat visceral fat or replace nutrition, activity or surgical fat removal.
The number of sessions depends on the treatment area, tissue pattern, severity and individual response. Some patients may require a treatment series, while others may not be suitable at all. The doctor should review progress before recommending additional treatment.
Plan your next step
Share your goals with the Eco Botanic team and begin with a personalised consultation.